Issue 35, 2022

Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application

Abstract

The emergence of antibiotic resistance makes the therapeutic effect of traditional antibiotics far from satisfactory. Here, chiral gold nano-bipyramids (GBPs) with sea cucumber-like morphology are reported, and used in the fight against bacterial infection. Specifically, the dipeptide of D-/L-Cys-Phe (CF) caused the nano-bipyramids to form a spike shape with an optical anisotropy factor of 0.102 at 573 nm. The antibacterial effects showed that D-GBPs and L-GBPs could efficiently destroy bacteria with a death ratio of 98% and 70% in vitro. Also, both in vivo skin infection and sepsis models showed that the chiral GBPs could effectively promote wound healing and prevent sepsis in mice. Mechanistic studies showed that the binding affinity of D-GBPs (1.071 ± 0.023 × 108 M−1) was 12.39-fold higher than L-GBPs (8.664 ± 0.251 × 106 M−1) to protein A of Staphylococcus aureus, which caused further adsorption of D-GBPs onto the bacterial surface. Moreover, the physical destruction of the bacterial cell wall caused by the spike chiral GBPs, resulted in a stronger antibacterial effect for D-GBPs than L-GBPs. Furthermore, the excellent PTT of D-/L-GBPs further exacerbated the death of bacteria without any side-effect. Overall, chiral nano-bipyramids have opened a new avenue for improved antibacterial efficacy in the treatment of bacterial infections.

Graphical abstract: Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application

Supplementary files

Article information

Article type
Edge Article
Submitted
20 jun 2022
Accepted
22 jul 2022
First published
23 jul 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 10281-10290

Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application

P. Chen, G. Wang, C. Hao, W. Ma, L. Xu, H. Kuang, C. Xu and M. Sun, Chem. Sci., 2022, 13, 10281 DOI: 10.1039/D2SC03443C

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