Issue 1, 2022

Spatiotemporal dynamics of self-assembled structures in enzymatically induced agonistic and antagonistic conditions

Abstract

Predicting and designing systems with dynamic self-assembly properties in a spatiotemporal fashion is an important research area across disciplines ranging from understanding the fundamental non-equilibrium features of life to the fabrication of next-generation materials with life-like properties. Herein, we demonstrate a spatiotemporal dynamics pattern in the self-assembly behavior of a surfactant from an unorganized assembly, induced by adenosine triphosphate (ATP) and enzymes responsible for the degradation or conversion of ATP. We report the different behavior of two enzymes, alkaline phosphatase (ALP) and hexokinase (HK), towards adenosine triphosphate (ATP)-driven surfactant assembly, which also results in contrasting spatiotemporal dynamic assembly behavior. Here, ALP acts antagonistically, resulting in transient self-assemblies, whereas HK shows agonistic action with the ability to sustain the assemblies. This dynamic assembly behavior was then used to program the time-dependent emergence of a self-assembled structure in a two-dimensional space by maintaining concentration gradients of the enzymes and surfactant at different locations, demonstrating a new route for obtaining ‘spatial’ organizational adaptability in a self-organized system of interacting components for the incorporation of programmed functionality.

Graphical abstract: Spatiotemporal dynamics of self-assembled structures in enzymatically induced agonistic and antagonistic conditions

Supplementary files

Article information

Article type
Edge Article
Submitted
28 sep 2021
Accepted
20 nov 2021
First published
22 nov 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 274-282

Spatiotemporal dynamics of self-assembled structures in enzymatically induced agonistic and antagonistic conditions

Priyanka, E. Shandilya, S. K. Brar, R. R. Mahato and S. Maiti, Chem. Sci., 2022, 13, 274 DOI: 10.1039/D1SC05353A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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