Issue 51, 2022

Annulations involving 1-indanones to access fused- and spiro frameworks

Abstract

Indanones are prominent motifs found in number of natural products and pharmaceuticals. Particularly, 1-indanones occupy important niche in chemical landscape due to their easy accessibility and versatile reactivity. In the past few years, significant advancement has been achieved regarding cyclization of 1-indanone core. The present review focuses on recent (2016–2022) annulations involving 1-indanones for the construction of fused- and spirocyclic frameworks. In this context, new strategies for synthesis of various carbocyclic as well as heterocyclic skeletons are demonstrated. Mechanistic aspects of representative reactions are illustrated for better understanding of reaction pathways. A large number of transformations described in this review offer stereoselective formation of desired polycyclic compounds. Importantly, several reactions provide biologically relevant compounds and natural products, such as, plecarpenene/plecarpenone, swinhoeisterol A, cephanolides A–D, diptoindonesin G and atlanticone C.

Graphical abstract: Annulations involving 1-indanones to access fused- and spiro frameworks

Article information

Article type
Review Article
Submitted
20 okt 2022
Accepted
16 nov 2022
First published
22 nov 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 33365-33402

Annulations involving 1-indanones to access fused- and spiro frameworks

S. Das and A. Dutta, RSC Adv., 2022, 12, 33365 DOI: 10.1039/D2RA06635A

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