Issue 48, 2022

Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection

Abstract

An immunosensor is defined as an analytical device that detects the binding of an antigen to its specific antibody by coupling an immunochemical reaction to the surface of a device called a transducer. Fluorescence immunosensing is one of the most promising immunoassays at present, and has the advantages of simple operation, fast response and high stability. A traditional fluorescence immunosensor often uses an enzyme-labelled antibody as a recognition unit and an organic dye as a fluorescence probe, so it is easily affected by environmental factors with low sensitivity. Nanomaterials have unique photostability, catalytic properties and biocompatibility, which open up a new path for the construction of stable and sensitive fluorescence immunosensors. This paper briefly introduces different kinds of immunosensors and the role of nanomaterials in the construction of immunosensors. The significance of fluorescent immunosensors constructed from functional nanomaterials to detect tumor biomarkers was analyzed, and the strategies to further improve the performance of fluorescent immunosensors and their future development trend were summarized.

Graphical abstract: Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection

Article information

Article type
Review Article
Submitted
10 aug 2022
Accepted
19 okt 2022
First published
01 nov 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 31369-31379

Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection

J. Huang, F. Wei, Y. Cui, L. Hou and T. Lin, RSC Adv., 2022, 12, 31369 DOI: 10.1039/D2RA04989A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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