Issue 17, 2022

Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

Abstract

Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo2(OAc)4 induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC50 values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively.

Graphical abstract: Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

Supplementary files

Article information

Article type
Paper
Submitted
15 mar 2022
Accepted
24 mar 2022
First published
06 apr 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 10646-10652

Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

D. T. Trang, D. T. T. Hang, D. T. Dung, N. T. Cuc, P. H. Yen, P. T. T. Huong, L. T. Huyen, N. T. Mai, N. X. Nhiem, B. H. Tai and P. Van Kiem, RSC Adv., 2022, 12, 10646 DOI: 10.1039/D2RA01674E

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