Issue 18, 2022

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

Abstract

Autophagy is an evolutionarily conserved catabolic process that can degrade cytoplasmic materials and recycle energy to maintain metabolite homeostasis in cells. Autophagy is closely related to various physiological or pathological processes. Macromolecular materials are widely used in drug delivery systems and disease treatments due to their intrinsic effects, such as altered pharmacokinetics and biodistribution. Interaction of autophagic flux or the signal pathway with macromolecules may cause autophagy inhibition or autophagy cell death. This review covers autophagy regulation pathways and macromolecular materials (including functional micelles, biodegradable and pH-sensitive polymers, biomacromolecules, dendrimers, coordination polymers, and hybrid nanoparticles) mediated autophagy modulation.

Graphical abstract: Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

Article information

Article type
Review Article
Submitted
06 jun 2022
Accepted
18 jul 2022
First published
20 jul 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 3676-3688

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

C. Wang, Y. Li, Y. Tian, W. Ma and Y. Sun, Nanoscale Adv., 2022, 4, 3676 DOI: 10.1039/D2NA00355D

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