Issue 20, 2022

Base-selective access to highly functionalized heterocycles from multicomponent Ugi adducts

Abstract

Selection of the appropriate base in Ugi/post-condensation sequences allows the selective syntheses of different ring-size functionalized lactams. The developed methodology uses inexpensive bases under mild and non-sensitive conditions leading to the facile generation of molecular diversity from simple synthons.

Graphical abstract: Base-selective access to highly functionalized heterocycles from multicomponent Ugi adducts

Supplementary files

Article information

Article type
Paper
Submitted
03 aug 2022
Accepted
23 sep 2022
First published
28 sep 2022
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2022,24, 7988-7995

Base-selective access to highly functionalized heterocycles from multicomponent Ugi adducts

B. González-Saiz, P. Pertejo, P. Peña-Calleja, M. Mielczarek, T. Hermosilla, I. Carreira-Barral, O. de Miguel, F. Rodríguez-Vidal, R. Quesada and M. García-Valverde, Green Chem., 2022, 24, 7988 DOI: 10.1039/D2GC02896D

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