Issue 37, 2022

Bismuth gallate coordination networks inspired by an active pharmaceutical ingredient

Abstract

The effect of solvent has been investigated for the synthesis of bismuth gallate compounds, of which the water-based bismuth subgallate has been used as an active pharmaceutical ingredient (API) for over a century. Using methanol as a solvent, two new bismuth gallates were acquired: first a flexible 3-periodic metal–organic framework (MOF) forms, which transforms upon extended synthesis times into a layered 2-periodic coordination polymer of the same bismuth-to-gallate ratio. The structures were determined by three-dimensional electron diffraction. Synthesis in ethanol resulted in the formation of the MOF phase, but not the layered phase. The layered material of the methanol-based synthesis was used as a Lewis acid catalyst due to its higher stability, showing a comparatively quick and regiospecific conversion of styrene oxide to 2-methoxy-2-phenylethanol, indicating the presence of open metal sites in the material. The acquisition of bismuth gallate structures of varying periodicity highlights the prospect of acquiring novel MOFs and coordination polymers from the same components of APIs.

Graphical abstract: Bismuth gallate coordination networks inspired by an active pharmaceutical ingredient

Supplementary files

Article information

Article type
Paper
Submitted
12 jul 2022
Accepted
26 aug 2022
First published
29 aug 2022
This article is Open Access
Creative Commons BY license

Dalton Trans., 2022,51, 14221-14227

Bismuth gallate coordination networks inspired by an active pharmaceutical ingredient

E. Svensson Grape, V. Rooth, S. Smolders, A. Thiriez, S. Takki, D. De Vos, T. Willhammar and A. K. Inge, Dalton Trans., 2022, 51, 14221 DOI: 10.1039/D2DT02260E

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