Issue 100, 2022

Organocatalyst based cross-catalytic system

Abstract

We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.

Graphical abstract: Organocatalyst based cross-catalytic system

Supplementary files

Article information

Article type
Communication
Submitted
20 okt 2022
Accepted
18 nov 2022
First published
18 nov 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 13895-13898

Organocatalyst based cross-catalytic system

M. J. Veenstra and S. R. Harutyunyan, Chem. Commun., 2022, 58, 13895 DOI: 10.1039/D2CC05610K

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