TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress

Kai-Cheng Yan; Bethany L. Patenall; Jordan E. Gardiner; Rachel A. Heylen; Naing Thet; Xiao-Peng He; Adam C. Sedgwick; Tony D. James; A. Toby A. Jenkins

doi:10.1039/D2CC04662H

TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress†

Kai-Cheng Yan,

^ac Bethany L. Patenall,

^a Jordan E. Gardiner,

^a Rachel A. Heylen,

^a Naing Thet,

^a Xiao-Peng He,

^c Adam C. Sedgwick,

*^b Tony D. James

*^ad and A. Toby A. Jenkins

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk, a.t.a.jenkins@bath.ac.uk

^b Chemistry Research Laboratory, University of Oxford, Mansfield Road, UK

^c Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai, China

^d School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China

Abstract

We report on a superoxide anion (O₂˙⁻) responsive fluorescent probe called TCF-OTf. TCF-OTf is able to monitor O₂˙⁻ production when the bacterial species Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis are exposed to chloramphenicol and heat shock at 50 and 58 °C.

This article is part of the themed collection: Chemosensors and Molecular Logic

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DOI: https://doi.org/10.1039/D2CC04662H
Article type: Communication
Submitted: 22 aug 2022
Accepted: 17 okt 2022
First published: 07 nov 2022
This article is Open Access

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Chem. Commun., 2022,58, 13103-13106

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TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress

K. Yan, B. L. Patenall, J. E. Gardiner, R. A. Heylen, N. Thet, X. He, A. C. Sedgwick, T. D. James and A. T. A. Jenkins, Chem. Commun., 2022, 58, 13103 DOI: 10.1039/D2CC04662H

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Chemical Communications

TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress†

Abstract

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TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress

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