Issue 75, 2022

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Abstract

Naphthalimide-based fluorescent probes (NAN0-N3 and NAN6-N3) were developed with dual locked fluorescence. Here, ≥1.9 × 10−2 mM of H2S and ≥2.2 × 10−2 μg mL−1 of DNA could unlock a highly sensitive off–on fluorescence response through synergistic changes of the molecular structure and conformation. As such, the probes could monitor DNA damage induced by the overexpression of H2S, and were able to evaluate the degree of apoptosis of living cells mediated by H2S-induced mtDNA or nDNA damage.

Graphical abstract: Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Supplementary files

Article information

Article type
Communication
Submitted
29 jul 2022
Accepted
23 aug 2022
First published
31 aug 2022

Chem. Commun., 2022,58, 10500-10503

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Y. Wang, X. Zhao, Y. Chen, T. D. James, G. Wang and H. Zhang, Chem. Commun., 2022, 58, 10500 DOI: 10.1039/D2CC04247A

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