Issue 25, 2021

Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study

Abstract

Bimodal sub-5 nm superparamagnetic iron oxide nanoparticles (SPIO-5) coated with polyethylene glycol of different chain lengths (i.e. PEG-800, -2000 and -5000) have been prepared and characterized. Fluorescence properties have been obtained by mean of the grafting of a near-infrared-emitting dye (NIR-dye) onto the surface of the oxide, thanks to the carboxylic acid functions introduced towards an organosilane coating. Such modification allowed us to follow in vivo their biodistribution and elimination pathways by T1–w and T2–w high-field magnetic resonance imaging (MRI), as well as by optical and optoacoustic imaging. Interestingly, it has been highlighted that for a given composition, the thickness of the coating strongly influences the pharmacokinetic properties of the administrated SPIO-5.

Graphical abstract: Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study

Supplementary files

Article information

Article type
Paper
Submitted
16 mar 2021
Accepted
26 mai 2021
First published
16 jun 2021

J. Mater. Chem. B, 2021,9, 5055-5068

Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study

D. Stanicki, L. Larbanoix, S. Boutry, T. Vangijzegem, I. Ternad, S. Garifo, R. N. Muller and S. Laurent, J. Mater. Chem. B, 2021, 9, 5055 DOI: 10.1039/D1TB00573A

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