Issue 35, 2021

Fluorescent probes for visualizing ROS-associated proteins in disease

Abstract

Abnormal expression of proteins, including catalytic and expression dysfunction, is directly related to the development of various diseases in living organisms. Reactive oxygen species (ROS) could regulate protein expression by redox modification or cellular signal pathway and thus influence the development of disease. Determining the expression level and activity of these ROS-associated proteins is of considerable importance in early-stage disease diagnosis and the identification of new drug targets. Fluorescence imaging technology has emerged as a powerful tool for specific in situ imaging of target proteins by virtue of its non-invasiveness, high sensitivity and good spatiotemporal resolution. In this review, we summarize advances made in the past decade for the design of fluorescent probes that have contributed to tracking ROS-associated proteins in disease. We envision that this review will attract significant attention from a wide range of researchers in their utilization of fluorescent probes for in situ investigation of pathological processes synergistically regulated by both ROS and proteins.

Graphical abstract: Fluorescent probes for visualizing ROS-associated proteins in disease

Article information

Article type
Review Article
Submitted
19 apr 2021
Accepted
06 jul 2021
First published
24 aug 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 11620-11646

Fluorescent probes for visualizing ROS-associated proteins in disease

H. Wang, X. Wang, P. Li, M. Dong, S. Q. Yao and B. Tang, Chem. Sci., 2021, 12, 11620 DOI: 10.1039/D1SC02165F

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