Issue 52, 2021

An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold

Abstract

In the field of drug discovery, isoxazole is a five-membered heterocyclic moiety commonly found in many commercially available drugs. In view of their enormous significance, it is always imperative to unleash new eco-friendly synthetic strategies. Among various novel synthetic techniques in use for isoxazole synthesis, most synthetic methods employ Cu(I) or Ru(II) as catalysts for (3 + 2) cycloaddition reaction. The particular disadvantages associated with metal-catalyzed reactions are high costs, low abundance, toxicity, a significant generation of waste, and difficulty to separate from the reaction mixtures. In view of these drawbacks, it is always imperative to develop alternate metal-free synthetic routes. This review article highlights a comprehensive overview on the potential application of metal-free synthetic routes for the synthesis of isoxazoles with significant biological interests.

Graphical abstract: An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold

Article information

Article type
Review Article
Submitted
15 jun 2021
Accepted
11 sep 2021
First published
06 okt 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 32680-32705

An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold

S. Das and K. Chanda, RSC Adv., 2021, 11, 32680 DOI: 10.1039/D1RA04624A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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