Issue 14, 2021

Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

Abstract

The development of carbamoyl chlorides as synthons for various amide-containing molecules and heterocycles has been summarized and discussed in this review article. Carbamoyl chlorides can participate in a diverse range of transition metal-catalyzed transformations including radical initiated reactions and cross-coupling and annulation reaction modes as well as C–H functionalization to access amide-functionalized organic frameworks having extensive applications in pharmaceutical and natural product synthesis. This review mainly highlights the advancements of carbamoyl chlorides as a powerful synthetic tool in transition-metal catalyzed reactions over the last two decades. In addition, transition-metal catalyzed reactions of their corresponding structural analogs, carbamoyl fluorides and cyanides, with respect to their chemical behavior are also briefly reviewed.

Graphical abstract: Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

Article information

Article type
Review Article
Submitted
13 jan 2021
Accepted
07 apr 2021
First published
19 apr 2021

Org. Chem. Front., 2021,8, 4024-4045

Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

M. Shrestha, X. Wu, W. Huang, J. Qu and Y. Chen, Org. Chem. Front., 2021, 8, 4024 DOI: 10.1039/D0QO01648A

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