Issue 33, 2021

Synthesis and self-assembly of amphiphilic precision glycomacromolecules

Abstract

We present the synthesis of so called amphiphilic glycomacromolecules (APGs) by using solid-phase polymer synthesis. Based on tailor made building blocks, monodisperse APGs with varying compositions are synthesized, introducing carbohydrate side chains and crosslinkable units at defined positions within the macromolecule. Self-assembly of the APGs is characterized via spectroscopic as well as scattering techniques and reveals structural dependencies between APG composition and self-assembly behavior such as the formation of spherical vs. worm-like micelles. Furthermore, polymerizable units within the APGs allow for fixation of the self-assembled structures. Carbohydrate presenting micelles are then evaluated as inhibitors of bacterial adhesion demonstrating their potential for biomedical applications.

Graphical abstract: Synthesis and self-assembly of amphiphilic precision glycomacromolecules

Supplementary files

Article information

Article type
Paper
Submitted
26 mar 2021
Accepted
17 mai 2021
First published
17 mai 2021
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2021,12, 4795-4802

Synthesis and self-assembly of amphiphilic precision glycomacromolecules

A. Banger, J. Sindram, M. Otten, J. Kania, D. Wilms, A. Strzelczyk, S. Miletic, T. C. Marlovits, M. Karg and L. Hartmann, Polym. Chem., 2021, 12, 4795 DOI: 10.1039/D1PY00422K

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