Issue 17, 2021

Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids

Abstract

An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.

Graphical abstract: Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids

Supplementary files

Article information

Article type
Communication
Submitted
11 feb 2021
Accepted
08 apr 2021
First published
08 apr 2021

Org. Biomol. Chem., 2021,19, 3838-3843

Author version available

Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids

S. R. Herschede, H. Gneid, T. Dent, E. B. Jaeger, L. B. Lawson and N. Busschaert, Org. Biomol. Chem., 2021, 19, 3838 DOI: 10.1039/D1OB00263E

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