Issue 45, 2021

A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

Abstract

Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.

Graphical abstract: A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

Supplementary files

Article information

Article type
Communication
Submitted
05 jun 2021
Accepted
27 sep 2021
First published
28 sep 2021

Nanoscale, 2021,13, 18941-18946

A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA

S. Uchida, Y. Yamaberi, M. Tanaka and M. Oba, Nanoscale, 2021, 13, 18941 DOI: 10.1039/D1NR03600A

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