Issue 12, 2021

Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

Abstract

In their role as pattern-recognition receptors on cells of the innate immune system, myeloid C-type lectin receptors (CLRs) assume important biological functions related to immunity, homeostasis, and cancer. As such, this family of receptors represents an appealing target for therapeutic interventions for modulating the outcome of many pathological processes, in particular related to infectious diseases. This review summarizes the current state of research into glycomimetic or drug-like small molecule ligands for the CLRs Mincle, Langerin, and DC-SIGN, which have potential therapeutic applications in vaccine research and anti-infective therapy.

Graphical abstract: Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

Article information

Article type
Review Article
Submitted
15 jul 2021
Accepted
14 sep 2021
First published
16 sep 2021
This article is Open Access
Creative Commons BY-NC license

RSC Med. Chem., 2021,12, 1985-2000

Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

J. Cramer, RSC Med. Chem., 2021, 12, 1985 DOI: 10.1039/D1MD00238D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements