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Issue 4, 2020
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Single-photon-driven up-/down-conversion nanohybrids for in vivo mercury detection and real-time tracking

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Abstract

A multifunctional assay with up-/down-conversion (UC/DC) nanohybrids which enables the detection and real-time tracking of hazardous molecules has been developed for use in the field of photoluminescence (PL) point-of-care testing due to its cost and convenience. In particular, innovative approaches such as dual or multimodal imaging and detection under only a single-photon pulse system are highly difficult owing to the issues of device simplification and miniaturization. In this work, we first demonstrated single-photon-driven UC/DC dual-modal PL nanohybrids and showed their high performance in in vivo mercury detection and real-time tracking in a mussel simultaneously. Specifically, UC/DC nanohybrids capable of being stimulated by a single photon were presented via a facile and versatile strategy by combining DC fluorophores for heavy metal ion screening with triplet–triplet annihilation upconversion (TTA-UC) nanocapsules for real-time tracking. By adopting the advantages of the structural transformation of DC fluorophores and highly stable TTA-UC nanocapsules, the outstanding monitoring performance of a standard heavy metal ion (i.e. Hg2+) was achieved by a dual-modal PL assay with nanohybrids, exhibiting ultra-sensitivity (under 1 nM) and high-selectivity. Interestingly, their application in the real world was also remarkable in screening and tracking of mercury in mussels. This single-photon-driven UC/DC convergence system will provide powerful analytical methodologies for target detection and real-time tracking in vivo and will attract widespread attention from researchers in the fields of PL nanomaterials and fluorophores.

Graphical abstract: Single-photon-driven up-/down-conversion nanohybrids for in vivo mercury detection and real-time tracking

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Supplementary files

Article information


Submitted
03 okt 2019
Accepted
03 des 2019
First published
04 des 2019

J. Mater. Chem. A, 2020,8, 1668-1677
Article type
Paper

Single-photon-driven up-/down-conversion nanohybrids for in vivo mercury detection and real-time tracking

S. E. Seo, C. S. Park, S. J. Park, K. H. Kim, J. Lee, J. Kim, S. H. Lee, H. S. Song, T. H. Ha, J. Kim, H. W. Yim, H. Kim and O. S. Kwon, J. Mater. Chem. A, 2020, 8, 1668
DOI: 10.1039/C9TA10921H

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