1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Min-Qi Hu; Heng Li; Ying Lin; Ying Zhang; Jie Tang; Jian-Ping Zuo; Li-Fang Yu; Xian-Kun Tong; Wei Tang; Fan Yang

doi:10.1039/D0RA08442E

1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors†

Min-Qi Hu,‡^a Heng Li,‡^bc Ying Lin,^a Ying Zhang,^a Jie Tang,^ad Jian-Ping Zuo,^b Li-Fang Yu,

^a Xian-Kun Tong,*^bc Wei Tang*^bc and Fan Yang

*^a

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* Corresponding authors

^a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China
E-mail: fyang@chem.ecnu.edu.cn

^b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
E-mail: tangwei@simm.ac.cn, xktong@simm.ac.cn

^c School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

^d Shanghai Greenchem & Biotech Co. Ltd., Shanghai, China

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

This article is part of the themed collection: 2020 RSC Advances HOT Article Collection

RSC Advances

1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors†

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1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

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