Issue 10, 2020

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

Supplementary files

Article information

Article type
Communication
Submitted
31 jan 2020
Accepted
06 feb 2020
First published
06 feb 2020

Org. Biomol. Chem., 2020,18, 1881-1885

Author version available

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

J. C. Maza, A. V. Ramsey, M. Mehare, S. W. Krska, C. A. Parish and M. B. Francis, Org. Biomol. Chem., 2020, 18, 1881 DOI: 10.1039/D0OB00211A

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