Issue 1, 2020

Engineering proteinosomes with renewable predatory behaviour towards living organisms

Abstract

Communication is a fundamental feature of life, and all living organisms interact actively with their surroundings to better their chance of survival through the coordination of group behavior. To develop mutual interactions between an artificial cell and living organism, we constructed a positively charged thermo-sensitive proteinosome with loaded L-arginine modified chitosan oligosaccharide as an antimicrobial in the hydrogel-based core domain, and then by controlling the temperature and ionic strength we demonstrate that changes in both the hydrophobicity and the electrostatic attraction allowed the constructed proteinosomes to show a programmed interaction with the living organism E. coli, including capture, aggregation induced self-suicide, release, and then the renewal of the proteinosomes. It is anticipated that our results will contribute to the development of the communication behaviours within artificial cell and living organism hybrid microsystems, and lay a foundation for further engineering artificial cell models towards biology inspired materials.

Graphical abstract: Engineering proteinosomes with renewable predatory behaviour towards living organisms

Supplementary files

Article information

Article type
Communication
Submitted
25 jun 2019
Accepted
09 aug 2019
First published
09 aug 2019

Mater. Horiz., 2020,7, 157-163

Engineering proteinosomes with renewable predatory behaviour towards living organisms

C. Zhao, M. Zhu, Y. Fang, X. Liu, L. Wang, D. Chen and X. Huang, Mater. Horiz., 2020, 7, 157 DOI: 10.1039/C9MH00976K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements