Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity

Olga A. Kraevaya; Artem V. Novikov; Alexander F. Shestakov; Elizaveta S. Ershova; Ekaterina A. Savinova; Larisa V. Kameneva; Nataliya N. Veiko; Dominique Schols; Jan Balzarini; Svetlana V. Kostyuk; Pavel A. Troshin

doi:10.1039/D0CC03928D

Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity†

Olga A. Kraevaya,

*^ab Artem V. Novikov,

^ab Alexander F. Shestakov,^bc Elizaveta S. Ershova,^d Ekaterina A. Savinova,^d Larisa V. Kameneva,^d Nataliya N. Veiko,^d Dominique Schols,^e Jan Balzarini,^e Svetlana V. Kostyuk^d and Pavel A. Troshin

^ab

Author affiliations

* Corresponding authors

^a Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, Russia
E-mail: okraevaya@inbox.ru

^b IPCP RAS, Semenov Prospect 1, Chernogolovka, Russia

^c Department of Physical and Chemical Engineering, Lomonosov Moscow State University, Moscow, Russia

^d Research Centre for Medical Genetics RAMS, Moskvorech’e St. 1, Moscow, Russia

^e Rega Institute for Medical Research, KU Leuven, Herestraat 49, Leuven, Belgium

Abstract

Here we report a straightforward method for the synthesis of a water-soluble C₆₀ fullerene derivative decorated with five residues of phosphonic acid. Self-assembly of the synthesized compound in aqueous solution leads to the formation of nanostructures with unprecedented myogenic and antiviral activity.

Chemical Communications

Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity†

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Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity

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