Issue 29, 2020

Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

Abstract

Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of ‘relaxivity’) stems from the restriction in motion experienced by the gadolinium chelates on being attached to the gold nanoparticle surface. More recently, the unique properties of gold nanoparticles have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies. This review addresses the progress made in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics. It also seeks to connect the chemical properties of these assemblies with potential application in the clinic.

Graphical abstract: Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

Article information

Article type
Highlight
Submitted
08 jan 2020
Accepted
23 mar 2020
First published
23 mar 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 4037-4046

Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

H. L. Perry, R. M. Botnar and J. D. E. T. Wilton-Ely, Chem. Commun., 2020, 56, 4037 DOI: 10.1039/D0CC00196A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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