Issue 18, 2019

A biocatalytic cascade for the conversion of fatty acids to fatty amines

Abstract

Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (ω-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C6 to C18, were successfully aminated obtaining conversions of up to 96%.

Graphical abstract: A biocatalytic cascade for the conversion of fatty acids to fatty amines

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
03 jul 2019
Accepted
30 aug 2019
First published
30 aug 2019

Green Chem., 2019,21, 4932-4935

A biocatalytic cascade for the conversion of fatty acids to fatty amines

J. Citoler, S. R. Derrington, J. L. Galman, H. Bevinakatti and N. J. Turner, Green Chem., 2019, 21, 4932 DOI: 10.1039/C9GC02260K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements