Issue 82, 2019

In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

Abstract

Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of β-galactosidase (β-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous β-gal activity in SKOV-3 cells and tumor-bearing mice.

Graphical abstract: In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

Supplementary files

Article information

Article type
Communication
Submitted
03 sep 2019
Accepted
19 sep 2019
First published
19 sep 2019

Chem. Commun., 2019,55, 12308-12311

In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

L. Shi, C. Yan, Y. Ma, T. Wang, Z. Guo and W. Zhu, Chem. Commun., 2019, 55, 12308 DOI: 10.1039/C9CC06869D

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