Issue 13, 2019

Recent development on the [5+2] cycloadditions and their application in natural product synthesis

Abstract

The [5+2] cycloaddition is one kind of fascinating and powerful reaction to access seven-membered ring systems existing in complex natural products and pharmaceuticals. In this review, recent developments on the [5+2] cycloadditions and their application in the synthesis of complex natural products are discussed. A focus is given to the way in which the [5+2] cycloadditions have influenced the logical process of the synthesis. This article is organized by reaction types, aiming to provide a clear clue to the latest research trends.

Graphical abstract: Recent development on the [5+2] cycloadditions and their application in natural product synthesis

Article information

Article type
Feature Article
Submitted
15 nov 2018
Accepted
15 jan 2019
First published
16 jan 2019

Chem. Commun., 2019,55, 1859-1878

Recent development on the [5+2] cycloadditions and their application in natural product synthesis

K. Gao, Y. Zhang, Z. Wang and H. Ding, Chem. Commun., 2019, 55, 1859 DOI: 10.1039/C8CC09077G

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