Issue 12, 2019
From the journal:

Chemical Communications

Photoenzymatic epoxidation of styrenes†

Morten M. C. H. van Schie, ORCID logo a   Caroline E. Paul, ORCID logo b   Isabel W. C. E. Arends ORCID logo c  and  Frank Hollmann ORCID logo *a  

* Corresponding authors

a Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands
E-mail: f.hollmann@tudelft.nl

b Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708WE Wageningen, The Netherlands

c Faculty of Science, University of Utrecht, The Netherlands

Abstract

Two-component-diffusible-flavomonooxygenases are versatile biocatalysts for selective epoxidation-, hydroxylation- or halogenation reactions. Their complicated molecular architecture can be simplified using photochemical regeneration of the catalytically active, reduced FADH2 prosthetic group. In this contribution we provide the proof-of-concept and characterization for the direct regeneration of the styrene monooxygenase from Pseudomonas.

Graphical abstract: Photoenzymatic epoxidation of styrenes

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Article information

DOI
https://doi.org/10.1039/C8CC08149B
Article type
Communication
Submitted
11 okt 2018
Accepted
18 des 2018
First published
22 jan 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 1790-1792

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Photoenzymatic epoxidation of styrenes

M. M. C. H. van Schie, C. E. Paul, I. W. C. E. Arends and F. Hollmann, Chem. Commun., 2019, 55, 1790 DOI: 10.1039/C8CC08149B

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