Issue 23, 2018

Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

Abstract

A highly regioselective C–C bond cleavage/amination of isatins has been developed for the synthesis of benzimidazo[1,2-c]quinazolin-6-ones by reacting with o-phenylene diamines. This practical transition-metal-free method is operationally simple, enabling the C–C bond cleavage and triple C–N bond formation, wherein molecular oxygen is the sole required oxidant.

Graphical abstract: Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

Supplementary files

Article information

Article type
Research Article
Submitted
26 sep 2018
Accepted
23 okt 2018
First published
25 okt 2018

Org. Chem. Front., 2018,5, 3464-3468

Direct construction of benzimidazo[l,2-c]quinazolin-6-ones via metal-free oxidative C–C bond cleavage

P. Li, C. Yan, S. Zhu, S. Liu and L. Zou, Org. Chem. Front., 2018, 5, 3464 DOI: 10.1039/C8QO01039K

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