Issue 1, 2018

A ratiometric fluorogenic probe for the real-time detection of SO32− in aqueous medium: application in a cellulose paper based device and potential to sense SO32− in mitochondria

Abstract

A new water soluble and fluorogenic probe (L) that can demonstrate a specific ratiometric detection of a SO2 derivative (SO32−) in 100% aqueous medium and live cells has been designed and synthesized. The detection process can be visualized by the naked eye, as the orange-red fluorescence of L turns into a strong blue fluorescence upon interaction with SO32−. L displayed several beneficial attributes such as detection in complete aqueous medium, extremely fast response time along with high selectivity and sensitivity. The ratiometric sensing was attributed to the selective nucleophilic addition reaction of SO32− with L. The probe was further used to develop a low cost microfluidic sensor device (μPAD). The probe was biocompatible and its potential to sense SO32− in mitochondria was captured in live HeLa cells.

Graphical abstract: A ratiometric fluorogenic probe for the real-time detection of SO32− in aqueous medium: application in a cellulose paper based device and potential to sense SO32− in mitochondria

Supplementary files

Article information

Article type
Paper
Submitted
17 aug 2017
Accepted
01 nov 2017
First published
08 nov 2017

Analyst, 2018,143, 250-257

A ratiometric fluorogenic probe for the real-time detection of SO32− in aqueous medium: application in a cellulose paper based device and potential to sense SO32− in mitochondria

S. Samanta, S. Halder, P. Dey, U. Manna, A. Ramesh and G. Das, Analyst, 2018, 143, 250 DOI: 10.1039/C7AN01368J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements