Issue 4, 2016

The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

Abstract

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper-catalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structural complexity of the natural product framework.

Graphical abstract: The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

Supplementary files

Article information

Article type
Edge Article
Submitted
17 nov 2015
Accepted
12 jan 2016
First published
21 jan 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 2706-2710

The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

J. C. Fox, R. E. Gilligan, A. K. Pitts, H. R. Bennett and M. J. Gaunt, Chem. Sci., 2016, 7, 2706 DOI: 10.1039/C5SC04399A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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