Issue 11, 2011

The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity

Abstract

Ni(II) ions are able to hydrolyze Naa-(Ser/Thr) peptide bonds in Naa-(Ser/Thr)-Xaa-His-Zaa sequences. We found that various human transcription factors contain such nickel hydrolytic patterns within C2H2 zinc finger (ZF) domains. We demonstrated the hydrolysis on two peptide models, the 3rd ZF of the Sp1 transcription factor and the 1st ZF of the ZNF302 transcription factor. The experimentally studied reaction rates indicate that the hydrolysis reaction is likely to be an element of intracellular nickel toxicity.

Graphical abstract: The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity

Supplementary files

Article information

Article type
Paper
Submitted
02 jul 2011
Accepted
08 aug 2011
First published
25 aug 2011

Metallomics, 2011,3, 1227-1231

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