Issue 16, 2024

Comparison of mechanochemical methods in the synthesis of binaphthol–benzoquinone based cocrystals

Abstract

Mechanochemical methods either under neat or liquid assisted conditions have proven to be successful in making cocrystals. In this paper we compare the outcome of cocrystallization using two different mechanochemical methods, ball milling (BM) and resonant acoustic mixing (RAM), with solution crystallization. Racemic binaphthol and benzoquinone based binary and ternary cocrystals were investigated by BM and RAM. Both mechanochemical methods were successful in making the binary and ternary cocrystals that have been observed in solid state and solution. It is shown that the type of mechanochemical force imparted to the sample is very different between BM and RAM and this in turn leads to different cocrystallization outcomes. Thus, different mechanochemical methods should not be treated as the same and care must be taken when choosing a mechanochemical method for a particular application.

Graphical abstract: Comparison of mechanochemical methods in the synthesis of binaphthol–benzoquinone based cocrystals

Supplementary files

Article information

Article type
Paper
Submitted
28 sep 2023
Accepted
08 apr 2024
First published
08 apr 2024

Phys. Chem. Chem. Phys., 2024,26, 12545-12551

Comparison of mechanochemical methods in the synthesis of binaphthol–benzoquinone based cocrystals

S. Nagapudi and K. Nagapudi, Phys. Chem. Chem. Phys., 2024, 26, 12545 DOI: 10.1039/D3CP04713J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements