Issue 16, 2023

Optochemical control of Cu(i) homeostasis in mammalian cells

Abstract

Copper can act as a double-edged sword as it can cause fatal diseases when in excess or shortage. Precise control of copper homeostasis is maintained by a complex machinery inside cells. To overcome imbalances in copper concentration, we have developed a simple system to control the cellular copper concentration by using a photocaged chelator and light. This photocaged chelator allowed us to control cellular copper concentration in a spatiotemporal manner.

Graphical abstract: Optochemical control of Cu(i) homeostasis in mammalian cells

Supplementary files

Article information

Article type
Communication
Submitted
28 okt 2022
Accepted
19 jan 2023
First published
20 jan 2023

Chem. Commun., 2023,59, 2315-2318

Optochemical control of Cu(I) homeostasis in mammalian cells

P. K. Pain, D. Palit, M. Shegane, R. P. Singh and D. Manna, Chem. Commun., 2023, 59, 2315 DOI: 10.1039/D2CC05830H

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