Issue 47, 2022

Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

Abstract

Parkinson's disease (PD) presents symptoms based mainly on motor changes; however, psychomotor and non-motor manifestations, such as anxiety-like behavior, learning, and memory deficits, also have a relevant impact on the individual's quality of life. Recently, 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) showed positive effects on motor and biochemical behavioral parameters in a model of PD, in Drosophila melanogaster. The present study aimed to evaluate the effects of 4-PSQ in the psychomotor and non-motor alterations in a mimetic model of PD induced by rotenone (ROT) in Drosophila melanogaster. Flies of both sexes with two days of age were used and divided into four groups: [1] control group, [2] 4-PSQ (25 μM) group, [3] ROT (500 μM) group, and [4] 4-PSQ (25 μM) + ROT (500 μM) group, exposed to a diet with ROT and/or 4-PSQ for seven days, according to each group. The open field and equilibrist test, aversive phototaxis suppression assay, light/dark exploration test, and the acetylcholinesterase (AChE) activity were performed. The treatment with 4-PSQ was effective in reversing the ROT-induced deficits in flies, improving spontaneous locomotor activity, learning, memory, and anxiety-like behavior. And the 4-PSQ was able to prevent the increase in the AChE activity in the head and body of flies exposed to ROT. The treatment with 4-PSQ was effective in the prevention of psychomotor and non-motor deficits in this mimetic model of PD, with effects possibly related to its anticholinesterase activity, associated with the multi-target action of 4-PSQ.

Graphical abstract: Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

Supplementary files

Article information

Article type
Paper
Submitted
17 aug 2022
Accepted
29 okt 2022
First published
16 nov 2022

New J. Chem., 2022,46, 22539-22549

Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

S. D. F. Couto, S. M. Araujo, V. C. Bortolotto, M. M. M. Dahleh, E. A. S. Musachio, F. C. Pinheiro, L. C. Romio, M. do Sacramento, D. Alves and M. Prigol, New J. Chem., 2022, 46, 22539 DOI: 10.1039/D2NJ04011E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements