Issue 14, 2021

Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

Abstract

Despite significant advances in NMR spectroscopy, structure elucidation of natural products, especially stereochemically complex polyketides with limited availability, is still a challenging task for chemists. Recent examples of structure determination, correction and disproof of structurally complex marine polyketide macrolides by chemical synthesis, namely lobatamide C, reidispongiolide A, callyspongiolide, palmerolide A, muironolide A, iriomoteolide-2a, and chagosensine cases, are summarized in this review, which highlights the scope and limitation of current NMR-based structure analysis and the vital role of chemical synthesis in structure elucidation.

Graphical abstract: Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

Article information

Article type
Review Article
Submitted
28 mar 2021
Accepted
24 apr 2021
First published
26 apr 2021

Org. Chem. Front., 2021,8, 3990-4023

Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

H. Fuwa, Org. Chem. Front., 2021, 8, 3990 DOI: 10.1039/D1QO00481F

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