Issue 14, 2021

Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds

Abstract

The C–F bond is the strongest single bond in organic compounds. It is the most challenging task to study the activation of the C–F bond in organic synthesis. Trifluoromethyl-containing compounds, which have three equivalent C–F bonds, constitute possible starting materials for the synthesis of diverse fluorinated compounds through selective C–F bond activation. In the past decades, significant progress has been made in the C–F bond activation of trifluoromethyl-containing compounds, mainly including trifluoromethylalkenes, trifluoromethylated aromatic and alkyl compounds, trifluoromethylketones, diazo compounds and N-tosylhydrazones of trifluoromethyl ketones, alkyltriflones, etc. In this review, we systematically summarized the C–F bond functionalization of these trifluoromethylated compounds, and their mechanisms were also discussed.

Graphical abstract: Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds

Article information

Article type
Review Article
Submitted
12 jan 2021
Accepted
31 mar 2021
First published
12 apr 2021

Org. Chem. Front., 2021,8, 3915-3942

Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds

G. Yan, K. Qiu and M. Guo, Org. Chem. Front., 2021, 8, 3915 DOI: 10.1039/D1QO00037C

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