Issue 20, 2021

Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

Abstract

Polyfluoro(aza)aromatic compounds are of interest in various fields of practical applications, such as medicinal and agrochemistry, materials science and advanced technologies. The C–C coupling reactions are known to be a promising synthetic tool to create challenging fluorinated molecules of diverse architectures. In this review, we have summarized the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021. Also, mechanistic features for chemical transformations of fluoroarene scaffolds and new opportunities for practical applications of the designed fluorinated molecules have been highlighted.

Graphical abstract: Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

Article information

Article type
Review Article
Submitted
10 mar 2021
Accepted
21 apr 2021
First published
22 apr 2021

Org. Biomol. Chem., 2021,19, 4429-4459

Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

T. D. Moseev, M. V. Varaksin, D. A. Gorlov, V. N. Charushin and O. N. Chupakhin, Org. Biomol. Chem., 2021, 19, 4429 DOI: 10.1039/D1OB00472G

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