Issue 93, 2021

Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy

Abstract

Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability in vivo, thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.

Graphical abstract: Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy

Article information

Article type
Feature Article
Submitted
30 aug 2021
Accepted
25 okt 2021
First published
04 nov 2021

Chem. Commun., 2021,57, 12417-12435

Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy

X. He, Z. Jiang, O. U. Akakuru, J. Li and A. Wu, Chem. Commun., 2021, 57, 12417 DOI: 10.1039/D1CC04846E

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