Issue 8, 2020

Cobalt-catalyzed regioselective hydrohydrazination of epoxides

Abstract

Using an air-stable cobalt catalyst [Cp*Co(1,2-Ph2PC6H4S)(NCMe)]BF4 (1, Cp* = Me5C5), we have achieved catalytic regioselective hydrohydrazination of epoxides to 1,1-hydrazinoalcohols in an atom-economical manner. The catalysis involves a cobalt–hydrazine intermediate, in which the NH2 group of the hydrazine binds to the metal center, inhibiting its nucleophilic reactivity and allowing the NH group to participate in the regioselective hydrohydrazination.

Graphical abstract: Cobalt-catalyzed regioselective hydrohydrazination of epoxides

Supplementary files

Article information

Article type
Communication
Submitted
08 jan 2020
Accepted
03 feb 2020
First published
03 feb 2020

Org. Biomol. Chem., 2020,18, 1572-1576

Cobalt-catalyzed regioselective hydrohydrazination of epoxides

X. Liu, H. Song, X. Zhai, C. Tung and W. Wang, Org. Biomol. Chem., 2020, 18, 1572 DOI: 10.1039/D0OB00037J

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