Issue 35, 2015

Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

Abstract

With inspirations from natural viruses, arginine-containing dendritic lipopeptides were designed for bioinspired fabrication. Self-assembling the defined amphiphilic lipopeptides generated virus-inspired nanovectors with an arginine-rich corona. These nanovectors provided some remarkable benefits for gene delivery, including well-defined nanostructure, high transfection efficiency, serum resistance and low cytotoxicity.

Graphical abstract: Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

Supplementary files

Article information

Article type
Communication
Submitted
03 jun 2015
Accepted
27 jul 2015
First published
28 jul 2015

J. Mater. Chem. B, 2015,3, 7006-7010

Author version available

Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

X. Xu, Q. Jiang, X. Zhang, Y. Nie, Z. Zhang, Y. Li, G. Cheng and Z. Gu, J. Mater. Chem. B, 2015, 3, 7006 DOI: 10.1039/C5TB01070E

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