Issue 2, 2015

Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

Abstract

A novel strategy for the cross dehydrogenative coupling (CDC) of acetophenone hydrazones and aldehydes has been developed for the synthesis of highly substituted pyrazoles. This work, for the first time, uses elemental sulfur as a promoter as well as a hydrogen acceptor in effecting the Csp3–Csp2 bond formation via C–H activation.

Graphical abstract: Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

Supplementary files

Article information

Article type
Communication
Submitted
16 okt 2014
Accepted
10 nov 2014
First published
10 nov 2014

Chem. Commun., 2015,51, 366-369

Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

R. Vanjari, T. Guntreddi, S. Kumar and K. N. Singh, Chem. Commun., 2015, 51, 366 DOI: 10.1039/C4CC08210A

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