Issue 77, 2013

Direct asymmetric syntheses of chiral aldehydes and ketonesvia N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

Abstract

This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.

Graphical abstract: Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

Article information

Article type
Feature Article
Submitted
18 jul 2013
Accepted
06 aug 2013
First published
08 aug 2013

Chem. Commun., 2013,49, 8586-8598

Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

S. G. Davies, A. M. Fletcher and J. E. Thomson, Chem. Commun., 2013, 49, 8586 DOI: 10.1039/C3CC45463K

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