Themed collection Top 50 Articles of 2016: Analytical, Biological and Medicinal Chemistry

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.

The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”

This review summarise the current stand and future perspective on synthetic peptide-based vaccines.

A universal sensing platform with significantly enhanced image contrast and apparent brightness in biological imaging applications.

A conceptual design for artificial antimicrobial viruses is described.

We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest.

A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

We describe a new mitochondria-targeting fluorescent probe MCY-BF₂ that is singularly sensitive and specifically responsive to mitochondrial polarity.

A selective quenched activity-based probe detects caspase-3 activity in the endoplasmic reticulum of cancerous cells during apoptosis.

The first near-infrared fluorescent probe to detect H₂Se with high sensitivity was explored in living cells and in mice.

A surrogate nucleobase based on 4,4'-cyanine provided up to 195-fold enhancement of red fluorescence upon complementary RNA binding. A mixture of FIT probes allowed the localization of oskar mRNA and other polyadenylated mRNA molecules in developing oocytes from Drosphila melanogaster by wash-free FISH and STED.

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.

A portable optoelectronic nose for the identification of explosives uses a highly cross-reactive colorimetric sensor array and a handheld scanner.

Free energy calculations based on molecular dynamics and thermodynamic cycles accurately reproduce experimental affinities of diverse bromodomain inhibitors.

A simple and versatile probe was discovered for discriminating between different thiol species with the use of CTAB (cetyl trimethylammonium bromide).