Themed collection 2021 RSC Advances HOT Article Collection

This review highlights the recent progress of Pd-catalyzed reactions in carbohydrates. Different types strategies and applications in the synthesis of natural products, SGLT2 inhibitors and biologically active have been included in this review.

Photoelectron photofragment coincidence spectroscopy studies of a range of carboxylate anions are reviewed, revealing details of the decarboxylation dynamics of carboxyl radicals.

Tubiechong, in Chinese medicine, denotes the dried female insects of Eupolyphaga sinensis Walker (ESW) or Polyphaga plancyi Bolivar (PPB).

This review discusses the chemical constituents and pharmacological effects of S. dulcis plants. S. dulcis provides new potential for medicine and can be promoted as a complementary or alternative therapy for patients with chronic conditions.

DNA interfaces with 0–3 dimensional materials through physisorption and chemisorption mechanisms acquire unique interfacial character for novel biomedical applications.

Glechomae Herba is a Chinese herb, which has been used in China for thousands of years, mainly for the treatment of nephrolithiasis.

A new asymmetric method for the synthesis of highly functionalized 4H-chromenes was developed via Group-Assisted Purification (GAP) chemistry and shown in good to high yield and excellent diastereoselectivity.

Cyanide-laden wastewaters are extremely toxic and it is of vital importance to treat them prior to discharge to receiving water resources.

Eleven new 9,19-cycloartane triterpenes (CTs) (1–9, 11–12) and one undescribed lanostane-type aglycone (10) were identified from Cimicifuga yunnanensis. CTs aglycones 7 and 8 potently down-regulated the mRNA expression of CD147, MMP-2, and MMP-9.

The inhibition mechanism of two homoisoflavonoids from Ophiopogon japonicus including methylophiopogonanone A (MO-A) and methylophiopogonanone B (MO-B) on tyrosinase (Tyr) was studied by multiple spectroscopic techniques and molecular docking.

Pd on N doped activated carbon exhibited increased activity and stability in 4-CBA hydrogenation relative to Pd catalysts without N doping. Higher dispersion of Pd⁰ and facile activation of H₂ accounted for the better activity of Pd/NC.

Muriolide, which is a natural lactone that was isolated from Ranunculus muricatus, is a promising natural radical scavenger in the physiological environment.

Chemical investigation of Aptenia cordifolia roots extract, using chromatographic and spectroscopic techniques, resulted in isolation and identification of eight known compounds.

The synthesis of several new compounds containing an ethanolamine moiety are reported, of which two exhibit promising antimicrobial activity (at the 6 μM level).

A broad spectrum ROS/RNS sensing butylated phenol tethered leucomethylene blue is presented. This probe detects a variety of ROS/RNS, with up to 100-fold gain in fluorescence in the red range, is suitable for microscopic and macroscopic in vivo fluorescence imaging.

In this study, liposome leakage using different liposome compositions and increased cellular permeability of human lung monolayer models induced by PHMG and PHMB were investigated.

Cheap and air-stable boric acid is shown to be a good precatalyst for BH₃ hydroboration of esters and carbonates.

Discovery of natural product inhibitors against human monoacylglycerol lipase by pharmacophore-based drug screening, LibDock molecular docking and in vitro biochemical examinations.

Mild lithography allows patterning of 2D materials while minimizing processing-induced defects. Thus, their structural integrity and intrinsic properties are preserved.

Synthesized hybrids of 1,2,4-oxadiazole and 1,3,4-oxadiazole connecting a penicillin and aliphatic amino acids displayed a high degree of cytotoxic selectivity.

A transition from catalytic to oxidative H₂O₂ decomposition on U₃O₈ was observed with NaHCO₃ with significant implications for uranium dissolution.

In this work, Nd₂WO₆ nanoparticles were synthesized by the ultrasonic method for the first time. Also, for the first time, the impact of these nanoparticles on the environment was investigated.

MMP-9 is a calcium-dependent zinc endopeptidase that plays a crucial role in various diseases and is a ubiquitous target for many classes of drugs.

In vitro systematic evaluation and network pharmacology analysis to explore the anti-tumor activities of thirty-seven diterpenoid alkaloids (DAs) from Aconitum carmichaelii Debx., including the first reported C₂₀-DA glucoside and three new C₁₉-DAs.

The synthesis of potassium 6-hydroxy-7-chloro-1,1-dimethyl-3,3-difluorobenzo-1,2,3-siloxaborolate 5b from readily available 4-bromo-2-chlorophenol was developed.

Reaction of benzimidazole derivatives with an isocyanide and acetone led to tricyclic benzodiazepine derivatives or dihydroquinoxalines depending on the nature of the substituents R¹ and R².

The evolution of the [Zr_xF_y]^4x−y ionic structures in FLiNaK–ZrF₄ salt mixtures was elucidated through solid-state NMR techniques when the melt salts were being solidified.

The cytotoxic potential of the crude extract, different fractions, and green synthesized nanoparticles of the soft coral Nephthea sp. was studied, supported by LC-HR-ESI-MS metabolomics analysis and molecular docking of the dereplicated compounds.

The reaction between hot atoms of fission product iodine causes its partial release and is affected by the redox condition of FLiBe salt.

Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads.

Preventing the biological activity of SARS-CoV-2 main protease using natural compounds is of great interest.

In this work, Tl₄HgI₆/HgI₂ nanocomposites were synthesized by a rapid ultrasonic method. The photocatalytic properties of the nanocomposites were evaluated for the first time. Photocatalytic properties were performed for six industrial dyes.

A combination of molecular docking and molecular dynamics simulation (250 ns) has been carried out to study the interaction of stilbenoid trimer compounds with the SIRT1 enzyme as the target protein.

A radiotracer ([¹⁸F]GCPA)₂ for sensitively and specifically detecting the expression level of γ-glutamyltranspeptidase in living subjects was reported.

N-heterocyclic carbene (NHC)-coordinated cyclometallated palladium complex (CYP) catalyzed (hetero)aryl addition of chloral hydrate using (hetero)arylboroxines, providing a new approach to 1-(hetero)aryl-2,2,2-trichloroethanols.

Approved drugs predicted to interact with critical residues in the substrate-binding site of SARS-CoV-2 Mpro can be promising inhibitors.

WS₂ 2D nanoparticles show no cytotoxic and/or cytostatic effect on Lewis lung carcinoma cells after one day incubation. Only after two days incubation we registered cytotoxic effect. Cells incubated with 2D WS₂ nanoparticles have luminescence in the blue spectral region.

A NiCo₂O₄/MnO₂ heterostructure with high mass loading MnO₂ microflowers was built on the surface of 3D graphene/nickel foam for the preparation of an asymmetric supercapacitor with splended energy density (45.9 Wh kg⁻¹).

The identification of AP-20 as a potential SARS COV-2 2′-O-methyltransferase inhibitor: fragment-based screening approach and MM-PBSA calculations.

Large composite particles of LiFePO₄ powders registered by TEM with at least 30% amount are recorded by XRD as smaller crystallites with at least 45% amount.

Several studies are now underway as a worldwide response for the containment of the COVID-19 outbreak; unfortunately, none of them have resulted in an effective treatment.

A colorimetric-fluorescent dual-signal lateral flow assay was proposed for the sensitive detection of S. aureus by using vancomycin-modified SiO₂–Au-QD tags.

We recently reported difference FTIR spectra upon binding of Ach to M₂R.

The present study reports trigonal phase molybdenum disulfide quantum dots (MoS₂/QDs)-decorated (Bi_1−xFe_x)VO₄ composite heterostructures.

Structure-based insilico-guided screening of potential polytargeting anti-COVID phytochemical: gallocatechin gallate analogue.

The Pd–NHC–MIL-101(Cr) catalyst was found to be an efficient heterogeneous catalyst in the synthesis of DSB and stilbene π-conjugated materials using Heck chemistry.

Highly active transmembrane anion carriers based on the 1,8-dithioamidocarbazole scaffold are presented, demonstrating the superior performance of thioamides as compared with their parent amides.

Identifying best bioactive phytochemicals from different medicinal plants using molecular docking techniques demonstrates a potential pre-clinical compound discovery against SARS-CoV-2 viral infection.

Cannabinoid and VOC emissions from vaping cannabis concentrates vary depending on terpene content, power level and consumption method.

MicroRNAs (miRNAs) play a pivotal role in cellular functions and in the development and progression of cancer.

Hybrid superparamagnetic nanoparticles functionalized with odorant binding proteins for Candida albicans treatment.

Biologically guided isolation of new factor Xa inhibitors from Glycyrrhiza glabra roots.

Pure anatase TiO₂ 2D IO films produced by “dynamic-hard-template infiltration” strategy simply using TiOSO₄ aqueous solution as precursor and templated from various PS spheres diameters exhibit distinct structural colors and EC optical modulation.

Solvent induced E–Z isomerization kinetics of some 3-(benzylidene)indolin-2-ones.

TEMPO is more effective than iodine in free-radical mediated, photochemical oxidative cyclization of stilbenes at elevated concentrations.

Using artificial intelligence technology to screen possible herbal drugs for Alzheimer's disease.

Known methods of synthesis of dihydropyrimidines and their oxidized products were modified, the impact of hydrogen bonds on stabilization of preferred tautomer and biological activities were studied.

The effect of dispersion interactions on the geometric and electronic properties of novel porous organic nanocrystals.

The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e. 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection.

Effect of substituents on the dihedral angle and chain packing plays a critical role in the enhancement in the gas separation performance of polymer membranes.

The performance of the quantum-dot light-emitting diodes was improved by using an organic–inorganic hybrid hole injection layer.

MWCNT-surface confined Hydroquinone/quinone redox system is prepared in situ method and used for mediated reduction of Cr(VI) species

Self-ordered anodic porous alumina with inter-hole spacing of 1.8 μm.

Transition metals enhance prebiotic proto-peptide oligomerization reactions through direct association with histidine.

Aggregation of intrinsically disordered as well as the ordered proteins under certain premises or physiological conditions leads to pathological disorder.

Salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels.

Ball mill ground IER waste form resulted in relatively better homogeneous waste distribution and displayed superior Cs leachability compared with the same polymer waste form prepared with non-ground IER.

The surge in vehicular activity in densely populated areas has led to an increased concentration of airborne palladium nanoparticles (PdNPs) in the environment.

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents.

A vast range of 2-amino-4,6-diphenylnicotinonitrile and 2,3-dihydroquinazolin-4(1H)-one were synthesized through a metal-free one-pot multi-component synthesis using β-cyclodextrin as an efficient supramolecular organocatalyst.