Themed collection Most popular analytical chemistry articles
![](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/Ajax-GA-Loader.gif)
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Droplet microfluidics: from proof-of-concept to real-world utility?
Droplet microfluidics constitutes a diverse and practical tool set that enables chemical and biological experiments to be performed at high speed and with enhanced efficiency when compared to conventional instrumentation.
Chem. Commun., 2019,55, 9895-9903
https://doi.org/10.1039/C9CC04750F
Metal–organic framework based nanozymes: promising materials for biochemical analysis
Metal–organic frameworks with enzyme-like catalytic features (MOF nanozymes) exhibit great promise in detecting various analytes with amplified signal outputs.
Chem. Commun., 2020,56, 11338-11353
https://doi.org/10.1039/D0CC04890A
Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes
This feature article comprehensively summarizes the development of small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes.
Chem. Commun., 2019,55, 6629-6671
https://doi.org/10.1039/C9CC03299A
Pushing the limits of electrochemistry toward challenging applications in clinical diagnosis, prognosis, and therapeutic action
Key aspects, current trends, and future perspectives with respect to electrochemical affinity biosensors for clinical diagnosis, prognosis, and therapeutic actions are discussed.
Chem. Commun., 2019,55, 2563-2592
https://doi.org/10.1039/C8CC08815B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Ratiometric sensing of fluoride ions using Raman spectroscopy
A simple ratiometric sensor based on Raman spectroscopy enables rapid fluoride ion detection in a paper-based assay using a portable spectrometer.
Chem. Commun., 2020,56, 14463-14466
https://doi.org/10.1039/D0CC05939K
A dual-ratiometric fluorescent probe for individual and continuous detection of H2S and HClO in living cells
A dual-ratiometric fluorescent probe, Han-HClO-H2S, was developed for the individual and continuous detection of H2S and HClO with high sensitivity and good selectivity, and had been applied to detect intracellular H2S and/or HClO in living cells.
Chem. Commun., 2020,56, 2849-2852
https://doi.org/10.1039/C9CC10028H
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation
A novel hepatocyte-targeting near-infrared ratiometric fluorescent probe named Gal-NIR is developed for detecting ONOO−. The probe can target the hepatocyte and assess drug-induced liver injury and its remediation in living cells and mice.
Chem. Commun., 2019,55, 14307-14310
https://doi.org/10.1039/C9CC07017F
Aptamer recognition-trigged label-free homogeneous electrochemical strategy for an ultrasensitive cancer-derived exosome assay
An aptamer recognition-trigged label-free homogeneous electrochemical strategy was developed for highly selective and ultrasensitive detection of cancer-derived exosomes.
Chem. Commun., 2019,55, 13705-13708
https://doi.org/10.1039/C9CC07253E
Construction of a two-photon fluorescent probe for ratiometric imaging of hypochlorous acid in alcohol-induced liver injury
A ratiometric two-photon fluorescent probe for HClO was deliberately constructed to reveal the generation of HClO in alcohol-induced liver injury.
Chem. Commun., 2019,55, 12912-12915
https://doi.org/10.1039/C9CC06888K
Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a
A novel ratiometric electrochemiluminescence–electrochemical hybrid biosensor with high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a.
Chem. Commun., 2019,55, 11551-11554
https://doi.org/10.1039/C9CC05592D
Development of a unique reversible fluorescent probe for tracking endogenous sulfur dioxide and formaldehyde fluctuation in vivo
A FRET-based reversible fluorescent probe for sensing SO2 and FA was designed. The probe was first used for imaging endogenous SO2 and FA in vitro and in vivo. Moreover, we first found that the interaction of SO2 and FA can reduce the cytotoxicity.
Chem. Commun., 2019,55, 11263-11266
https://doi.org/10.1039/C9CC04411F
Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity
A NIR fluorescent probe based on Si-rhodamine dithiobenzoic acid lactone was used to selectively visualize HOCl during GEN-induced nephrotoxicity for the first time.
Chem. Commun., 2019,55, 10916-10919
https://doi.org/10.1039/C9CC04736K
A three-dimensional DNA walker amplified FRET sensor for detection of telomerase activity based on the MnO2 nanosheet-upconversion nanoparticle sensing platform
We report a fluorescent sensing platform for telomerase activity assay by coupling a 3D DNA walker with the MnO2-UCNPs-based FRET system.
Chem. Commun., 2019,55, 9857-9860
https://doi.org/10.1039/C9CC05387E
A novel hydrosoluble near-infrared fluorescent probe for specifically monitoring tyrosinase and application in a mouse model
A novel hydrosoluble near-infrared fluorescent probe is applied to imaging and detection of endogenous tyrosinase in living cells, zebrafish and a mouse model.
Chem. Commun., 2019,55, 9463-9466
https://doi.org/10.1039/C9CC04714J
Rapid NMR assignments of intrinsically disordered proteins using two-dimensional 13C-detection based experiments
An approach for rapid resonance assignments in proteins based on 2D 13C-detected NMR experiments combined with amino acid selective unlabeling.
Chem. Commun., 2019,55, 7820-7823
https://doi.org/10.1039/C9CC03530C
Versatile “on–off” biosensing of thrombin and miRNA based on Ag(I) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification
A novel biosensing platform based on Ag(I) ion-enhanced or Ag nanoclusters (NCs)-quenched electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was designed for versatile “on–off” assays of thrombin (TB) and miRNA.
Chem. Commun., 2019,55, 7350-7353
https://doi.org/10.1039/C9CC03235E
A bright red-emitting flavonoid for Al3+ detection in live cells without quenching ICT fluorescence
A bright red-emitting flavonoid derivative was synthesized, which exhibited a large Stokes shift (Δλ > 150 nm) and high fluorescence quantum yields (ϕfl = 0.10–0.35).
Chem. Commun., 2019,55, 7041-7044
https://doi.org/10.1039/C9CC02322D
Near-infrared circularly polarized luminescence from chiral Yb(III)-diketonates
We report a rare example of near infrared circularly polarized luminescence (NIR-CPL) in the 920–1050 nm region associated with the f–f transitions of Yb diketonate complexes bearing chiral ancillary ligands.
Chem. Commun., 2019,55, 6607-6609
https://doi.org/10.1039/C9CC03032H
Bimodal detection of carbon dioxide using fluorescent molecular aggregates
Fluorescent aggregates of a cyano-substituted phenylenevinylene derivative (R-1) have been used as a bimodal probe for the easy and fast detection of CO2.
Chem. Commun., 2019,55, 6046-6049
https://doi.org/10.1039/C9CC01564G
A two-target responsive reversible ratiometric pH nanoprobe: a white light emitting quantum dot complex
Ratiometric pH sensing in the physiological range of pH 6.5–10.3 by a white light emitting quantum dot complex – following the changes in luminescence intensity ratio, color and chromaticity – is described herein.
Chem. Commun., 2019,55, 4331-4334
https://doi.org/10.1039/C9CC01088B
Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification
A novel DNA hydrogel-amplified versatile fluorescence platform combined with hybridization chain reaction (HCR) and DNA walking multiple amplification was developed for ultrasensitive detection of miRNA.
Chem. Commun., 2019,55, 3919-3922
https://doi.org/10.1039/C9CC00565J
A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region
An efficient fluorescence turn-on probe for amyloid detection in the extreme near-infrared region (>750 nm) with an exceptional red-shift in the absorption maxima is reported.
Chem. Commun., 2019,55, 3907-3910
https://doi.org/10.1039/C9CC01262A
A magnetic covalent organic framework as an adsorbent and a new matrix for enrichment and rapid determination of PAHs and their derivatives in PM2.5 by surface-assisted laser desorption/ionization-time of flight-mass spectrometry
Fe3O4@COFs served as an adsorbent and new matrix for SALDI-TOF-MS analysis of PAHs and their derivatives in PM2.5 with clear background, good reproducibility and sensitivity.
Chem. Commun., 2019,55, 3745-3748
https://doi.org/10.1039/C9CC00384C
Red-emitting pyrene–benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect
Pyrene–benzothiazolium probe for visualizing lysosome in live cells.
Chem. Commun., 2019,55, 3469-3472
https://doi.org/10.1039/C9CC01068H
Bridging exosome and liposome through zirconium–phosphate coordination chemistry: a new method for exosome detection
An exosomes–zirconium–liposomes sandwich structure is proposed to detect exosomes by using zirconium–phosphate coordination chemistry with lower cost, no modified label, and simplicity.
Chem. Commun., 2019,55, 2708-2711
https://doi.org/10.1039/C9CC00220K
A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid
A lysosome-targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid.
Chem. Commun., 2019,55, 2688-2691
https://doi.org/10.1039/C9CC00113A
A ratiometric fluorescent probe for detecting hypochlorite in the endoplasmic reticulum
A colorimetric and fluorescent probe ER-ClO was developed to detect cellular hypochlorite with high selectivity and sensitivity.
Chem. Commun., 2019,55, 2533-2536
https://doi.org/10.1039/C9CC00066F
Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy
A dual functional fluorescent molecular rotor was developed to trigger intracellular ER autophagy and quantify the local viscosity variations by FLIM imaging.
Chem. Commun., 2019,55, 2453-2456
https://doi.org/10.1039/C9CC00300B
A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues
Owing to the extreme toxicity of mercury, methods for its selective and sensitive sensing in solutions, and in live cells and tissues are in great demand.
Chem. Commun., 2019,55, 1766-1769
https://doi.org/10.1039/C8CC08608G
Real-time visualization of autophagy by monitoring the fluctuation of lysosomal pH with a ratiometric two-photon fluorescent probe
A ratiometric two-photon fluorescent probe (Lyso-MPCB) was developed for visualizing autophagy by real-time imaging the fluctuation of lysosomal pH.
Chem. Commun., 2019,55, 1782-1785
https://doi.org/10.1039/C8CC09517E
About this collection
This specially curated collection pulls together some of the most popular recent ChemComm articles in the field of analytical chemistry. The collection presents some outstanding contributions to the field, with research ranging from fluorescent probes for mercury detection to aptamer-binding DNA machines for the detection of tumor exosomes. We hope you enjoy browsing through this collection.