Heterocyclic quinolones are ubiquitous in nature and are vital structural motifs with widespread applications in organic synthesis and pharmaceuticals.
A wide scope methodology for the direct and modular synthesis of cyclopropane fused dihydroquinolones was developed from a unique α-diazo acylating agent, 2-(2-tosylhydrazineylidene)acetyl chloride.
An efficient protocol for the highly enantioselective synthesis of dihydroquinolones was developed via NHC-catalyzed [4 + 2] annulation between in situ generated aza-ortho-quinone methide and enolate intermediates.
Graphical representation of quinoline-based molecular frameworks: synthesis and structural diversity.
Quinoline plays a crucial role in drug development and pharmaceutical synthesis. This review highlights quinoline-based medications and their therapeutic potential, especially for malaria and cancer, impacting millions worldwide.