Heterocyclic quinolones are ubiquitous in nature and are vital structural motifs with widespread applications in organic synthesis and pharmaceuticals.
A ball milling promoted cross coupling of haloquinolines with potassium O-alkyl xanthates toward S-quinolyl xanthates under transition metal- and solvent-free conditions was developed.
An electrochemical dearomatization enables divergent C7 functionalization of quinolines via chlorocyclization or alkyl (aryl) migration.
An exceptional discovery of intermolecular cascade annulation for dihydrobenzo[b][1,8]naphthyridines involving specific aniline fragment transfer between Michael addition and SNAr has been reported.
Neglected tropical diseases (NTDs) encompass a broad spectrum of infectious diseases predominantly found in tropical and subtropical regions.