An electrochemical method for selenylating tetrahydroquinolines with diselenides is presented. By tuning reaction conditions, C-3 selenylated quinolines and C-6 selenylated tetrahydroquinolines can be selectively synthesized with excellent outcomes.
An electrochemical method is described for the direct oxidative C–N coupling of tetrahydroquinolines and azoles, enabling the synthesis of dihydroquinoline-azole and quinoline-azole derivatives under mild reaction conditions.
An efficient and practical bromination/dehydrogenation of tetrahydroquinolines was developed for the one-pot construction of polybromoquinolines under mild conditions. NBS not only acts as an electrophile, but also as an oxidant in this reaction.
We summarize the recent advances in the photocatalytic annulation of tertiary amines and maleimides for the synthesis of tetrahydroquinolines.
Glioblastoma multiforme (GBM) is an aggressive and treatment-resistant brain tumor.