An electrochemical method for selenylating tetrahydroquinolines with diselenides is presented. By tuning reaction conditions, C-3 selenylated quinolines and C-6 selenylated tetrahydroquinolines can be selectively synthesized with excellent outcomes.
An efficient and practical bromination/dehydrogenation of tetrahydroquinolines was developed for the one-pot construction of polybromoquinolines under mild conditions. NBS not only acts as an electrophile, but also as an oxidant in this reaction.
We summarize the recent advances in the photocatalytic annulation of tertiary amines and maleimides for the synthesis of tetrahydroquinolines.
Glioblastoma multiforme (GBM) is an aggressive and treatment-resistant brain tumor.
A unique imine-based covalent organic framework heterogeneous catalyst with missing-linker defects was designed and synthesized, and the catalyst exhibited excellent photocatalytic activity for efficient synthesis of tetrahydroquinolines.