A scalable synthesis of adjuvanting antigen depots based on metal–organic frameworks

Ryanne N. Ehrman, Olivia R. Brohlin, Yalini H. Wijesundara, Sneha Kumari, Orikeda Trashi, Thomas S. Howlett, Ikeda Trashi, Fabian C. Herbert, Arun Raja, Shailendra Koirala, Nancy Tran, Noora M. Al-Kharji, Wendy Tang, Milinda C. Senarathna, Laurel M. Hagge, Ronald A. Smaldone and Jeremiah J. Gassensmith

Chem. Sci., 2024, 15, 2731
DOI: 10.1039/D3SC06734C

Unleashing the antibacterial potential of ZIFs and their derivatives: mechanistic insights

Geetika Jain, Radhika Chaurasia, Bani Preet Kaur, Ontar Paul Chowdhury, Hiranmay Roy, Richa Rani Gupta, Bhaskar Biswas, Sandip Chakrabarti and Monalisa Mukherjee

J. Mater. Chem. B, 2025, 13, 3270
DOI: 10.1039/D4TB02682A

Magnetic MOF composites for the electrocatalysis and biosensing of dopamine released from living cells

Jiarong Guo, Ying Ma, Tongyu Han, Jiao Yang and Peng Miao

J. Mater. Chem. B, 2024, 12, 8181
DOI: 10.1039/D4TB00996G

Zeolitic imidazolate frameworks enhanced transfection efficiency of mRNA loaded lipid nanoparticles

Ruhani Singh, Kerri Bruce, Shen Y Heazlewood, Jacinta F White, Malisja de Vries, Benjamin W. Muir, Benjamin Cao, Xavier Mulet, Daniel Layton and Cara M. Doherty

J. Mater. Chem. B, 2025, 13, 10675
DOI: 10.1039/D4TB02101K

Improving the colloidal stability of protein@ZIF-8 nanoparticles in biologically relevant buffers

Justin Van Houten, Ruben Castillo Barberi, Jared King and Alana F. Ogata

Mater. Adv., 2024, 5, 5945
DOI: 10.1039/D4MA00377B

Testing the Antigenic Potential of Transmembrane Proteins To Develop a Thermostable Tuberculosis MOF-Liposomal Vaccine

Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Angelo Izzo, Blanca Restrepo, Lenette Lu, Gabriele Meloni and Jeremiah J. Gassensmith

ACS Infect. Dis., 2025, 11, 204
DOI: 10.1021/acsinfecdis.4c00771

Organophosphate Detoxification and Acetylcholinesterase Reactivation Triggered by Zeolitic Imidazolate Framework Structural Degradation

Javier D. Martin-Romera, Emilio Borrego-Marin, Pedro J. Jabalera-Ortiz, Francesco Carraro, Paolo Falcaro, Elisa Barea, Francisco J. Carmona and Jorge A. R. Navarro

ACS Appl. Mater. Interfaces, 2024, 16, 9900
DOI: 10.1021/acsami.3c18855

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Yalini H. Wijesundara, Thomas S. Howlett, Sneha Kumari and Jeremiah J. Gassensmith

Chem. Rev., 2024, 124, 3013
DOI: 10.1021/acs.chemrev.3c00409

Lipid/ZIF‐8 Biocomposites Based on Liposomes or Vesicles: In Situ Formation, and Preliminary Evaluation as Delivery Vehicles for Hydrophobic Drugs

Mary Cano‐Sarabia, Funda Aydin, Lingxin Meng, Marta Gil‐Bonillo, Javier Fonseca, Manuela Dietrich, Simon Renner, Heinz Amenitsch, Paolo Falcaro, Inhar Imaz and Daniel Maspoch

Small, 2025, 21
DOI: 10.1002/smll.202407051

Bacteriophage lysin-MOFs nanomaterials for treating apical periodontitis

Manhong Kuong, Haiping Wang, Feifei Han, Limei Fan, Fangfang Yao, Kai Yang, Xiaoying Hou, Zhengkai Li, Wanting He, Xiji Shu, Binlian Sun, Yuchen Liu and Yuhong Li

Journal of Controlled Release, 2025, 384, 113949
DOI: 10.1016/j.jconrel.2025.113949

Synthetic Aspects and Characterization Needs in MOF Chemistry – from Discovery to Applications

Bastian Achenbach, Aysu Yurdusen, Norbert Stock, Guillaume Maurin and Christian Serre

Advanced Materials, 2025
DOI: 10.1002/adma.202411359

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Alec Wang, Madeline Walden, Romy Ettlinger, Fabian Kiessling, Jeremiah J. Gassensmith, Twan Lammers, Stefan Wuttke and Quim Peña

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202308589

Advancements in chitosan-based nanocomposites with ZIF-8 nanoparticles: multifunctional platforms for wound healing applications

Mojtaba Tarin, Mahsa Akbari Oryani, Hossein Javid, Alireza Hashemzadeh and Mehdi Karimi-Shahri

Carbohydrate Polymers, 2025, 362, 123656
DOI: 10.1016/j.carbpol.2025.123656

A Self‐Adjuvanting Large Pore 2D Covalent Organic Framework as a Vaccine Platform

Yalini H. Wijesundara, Niyati Arora, Ryanne N. Ehrman, Thomas Sinclair Howlett, Trevor M. Weyman, Ikeda Trashi, Orikeda Trashi, Sneha Kumari, Shashini D. Diwakara, Wendy Tang, Milinda C. Senarathna, Katarzyna H. Drewniak, Ziqi Wang, Ronald A. Smaldone and Jeremiah J. Gassensmith

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202413020

Self‐Implantable Core–Shell Microneedle Patch for Long‐Acting Treatment of Keratitis via Programmed Drug Release

Xue Jiang, Yinli Jin, Yongnian Zeng, Peng Shi and Wei Li

Small, 2024, 20
DOI: 10.1002/smll.202310461

Linker Ratio‐Dependent Physicochemical Properties of ZIF‐8 Encapsulated Mini Protein 20 Mimicking Uricase

Siti Fatimah Nur Abdul Aziz, Abu Bakar Salleh, Yahaya M. Normi and Shahrul Ainliah Alang Ahmad

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400832

Mn and Zn‐Doped Multivariate Metal–Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection

Thomas S. Howlett, Sneha Kumari, Ryanne N. Ehrman, Jesse Masson, Linda Izzo, Trixie Wang, Humera Gull, Ikeda Trashi, Wendy Tang, Orikeda Trashi, Neha Satish, Yalini H. Wijesundara, Fabian C. Herbert, Angelo A. Izzo and Jeremiah J. Gassensmith

Adv Healthcare Materials, 2024
DOI: 10.1002/adhm.202402358

Enzyme-Activated Biosensor Assisted by Enzymatic Rolling Circle Amplification for Sensitive Detection of APE1 and Imaging in Vivo

Chuan Zhao, Siyuan Liu, Wenya Dang, Qing Liu, Danni Yin, Bin Liu and Chunsheng Hou

Anal. Chem., 2025, 97, 16690
DOI: 10.1021/acs.analchem.5c03866

Nanoscale ZIF-8 as an efficient carboplatin carrier for targeted cancer therapy

Toan Quyen Pham, Thanh Truc Nguyen, Huu Van Nguyen, Hoang Han Do, Ty Huynh Linh, Huong Thanh Thi Pham, Linh Ho Thuy Nguyen, Minh Tri Le and Tan Le Hoang Doan

Inorganic Chemistry Communications, 2024, 165, 112567
DOI: 10.1016/j.inoche.2024.112567

Metal–organic frameworks for biological applications

Isabel Abánades Lázaro, Xu Chen, Mengli Ding, Arvin Eskandari, David Fairen-Jimenez, Mónica Giménez-Marqués, Ruxandra Gref, Wenbin Lin, Taokun Luo and Ross S. Forgan

Nat Rev Methods Primers, 2024, 4
DOI: 10.1038/s43586-024-00320-8

Luminescent Nanocomposite SiO2/EuTTA/ZIF-8 Loaded with Uvaol: Synthesis, Characterization, Anti-Inflammatory Effects, and Molecular Docking Analysis

Rodrigo S. Viana, Polliane Maria Cavalcante de Araújo, Juliane Pereira da Silva, Jordana Rodrigues de Santana, Erick Gabriel Alves Ferreira, Alef Batista Bezerra Barros, Cintya D’ Angeles do Espírito Santo Barbosa, Carlos Américo Lechuga Puma, Larissa T. Jesus, Ricardo O. Freire, J. Michael Mathis, Emiliano Barreto and Severino Alves

ACS Omega, 2025, 10, 32391
DOI: 10.1021/acsomega.5c04682

A Self‐Adjuvanting Large Pore 2D Covalent Organic Framework as a Vaccine Platform

Yalini H. Wijesundara, Niyati Arora, Ryanne N. Ehrman, Thomas Sinclair Howlett, Trevor M. Weyman, Ikeda Trashi, Orikeda Trashi, Sneha Kumari, Shashini D. Diwakara, Wendy Tang, Milinda C. Senarathna, Katarzyna H. Drewniak, Ziqi Wang, Ronald A. Smaldone and Jeremiah J. Gassensmith

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202413020

Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni

Xianyuan Wei, Bin Xue, Shuangchen Ruan, Jintong Guo, Yujing Huang, Xiaorui Geng, Dan Wang, Cangtao Zhou, Jun Zheng and Zhen Yuan

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adk6331

Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing

Zhao Chen, Man Zhe, Wenting Wu, Peiyun Yu, Yuzhen Xiao, Hao Liu, Ming Liu, Zhou Xiang and Fei Xing

Pharmaceutics, 2024, 16, 1429
DOI: 10.3390/pharmaceutics16111429

Clinical translation of metal–organic frameworks

Nisha Tyagi, Yalini H. Wijesundara, Jeremiah J. Gassensmith and Amirali Popat

Nat Rev Mater, 2023, 8, 701
DOI: 10.1038/s41578-023-00608-3

Dual‐Fuel Propelled Nanomotors with Two‐Stage Permeation for Deep Bacterial Infection in the Treatment of Pulpitis

Heping Wang, Xi Chen, Lulu Zhang, Ziwei Han, Jinxin Zheng, Yilin Qi, Weitao Zhao, Xihan Xu, Tianqi Li, Yutong Zhou, Pingping Bao and Xue Xue

Advanced Science, 2024, 11
DOI: 10.1002/advs.202305063

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier

Anindita Chakraborty, Rajat Nandi, Diwakar Kumar and Himadri Acharya

ACS Omega, 2024
DOI: 10.1021/acsomega.3c09135

Zeolite imidazolate framework-8 in bone regeneration: A systematic review

Hao Tang, Yameng Yu, Xinxin Zhan, Yuan Chai, Yufeng Zheng, Yunsong Liu, Dandan Xia and Hong Lin

Journal of Controlled Release, 2024, 365, 558
DOI: 10.1016/j.jconrel.2023.11.049